Answer: MATTER
MATTER is a crossword puzzle answer that we have spotted 31 times.
Referring Clues:
- Concern
 - Mean something
 - Stuff
 - Space occupier
 - Make a difference
 - Be of consequence
 - See 19-Across
 - Count
 - Be important
 - Substance
 - "Anti" attachment
 - Physics concern
 - Have significance
 - Be important
 - Something to discuss
 - Physics topic
 - Word with dark or gray
 - Bear significance
 - Be relevant
 - Carry weight
 - "As a ___ of fact ..."
 - Subject
 - Something that occupies space
 - Physicist's study
 - Word that can follow the first parts of 17-, 25-, 42- and 55-Across
 - No laughing ___
 - Have some impact
 - "What's the ___?"
 - States of ___ (solid, liquid, gas, plasma)
 - Black Lives ___
 - "You're made of atoms. You ___!" (science pun)
 
Last Seen In:
- USA Today - October 22, 2025
 - USA Today - September 01, 2025
 - USA Today - January 08, 2025
 - USA Today - November 05, 2024
 - USA Today - October 21, 2024
 - LA Times - November 19, 2023
 - USA Today - November 01, 2023
 - USA Today - September 27, 2023
 - New York Times - January 15, 2023
 - LA Times - May 29, 2021
 - Netword - October 11, 2020
 - New York Times - September 07, 2020
 - Netword - September 06, 2020
 - LA Times - May 04, 2020
 - King Syndicate - Thomas Joseph - June 23, 2017
 - USA Today - May 22, 2017
 - King Syndicate - Premier Sunday - April 17, 2016
 - LA Times - March 23, 2016
 - Netword - January 23, 2016
 - New York Times - May 30, 2015
 
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