Answer: LYME
LYME is a crossword puzzle answer that we have spotted 30 times.
Referring Clues:
- Old ___, Conn.
 - East ___, Conn.
 - ___ disease
 - Connecticut town with a connection to tick bites
 - Connecticut town for which a tick-borne illness is named
 - __ disease: tick-borne illness
 - __ tick: disease carrier
 - Connecticut town for which a disease is named
 - Type of tick-borne disease
 - Tick-transmitted disease
 - ___ disease (tick affliction)
 - Old __, Connecticut
 - ___ disease: tick-borne illness
 - ___ tick: disease carrier
 - Old ___, Connecticut
 - Tick-borne disease
 - ___ disease (tick-borne ailment)
 - ___ disease: tick-transmitted affliction
 - Tick-borne affliction
 - See 62-Across
 - Connecticut community
 - East ___, Connecticut
 - Citrusy-sounding Connecticut town
 - Historic town in SE Connecticut
 - ___ disease, from ticks
 - Eponymous town in southeastern Connecticut
 - Disease namesake
 - Kind of disease with a telltale bull's-eye rash
 - Newcastle-under-___, Staffordshire, England
 - Tick-borne affliction, informally
 
Last Seen In:
- New York Times - September 11, 2025
 - New York Times - October 27, 2024
 - New York Times - October 05, 2024
 - LA Times - January 28, 2023
 - New York Times - August 07, 2022
 - New York Times - May 15, 2021
 - New York Times - September 17, 2020
 - LA Times - August 21, 2020
 - New York Times - July 11, 2020
 - Universal - August 03, 2019
 - New York Times - January 05, 2019
 - LA Times - October 11, 2018
 - USA Today - September 07, 2018
 - King Syndicate - Premier Sunday - April 22, 2018
 - New York Times - August 10, 2016
 - King Syndicate - Thomas Joseph - April 16, 2016
 - King Syndicate - Premier Sunday - November 15, 2015
 - LA Times - September 10, 2015
 - New York Times - January 18, 2015
 - LA Times - August 01, 2014
 
Seen a clue for the answer lyme that we don't have? Then please submit it to us so we can make the clue database even better!