Answer: HYDRA
HYDRA is a crossword puzzle answer that we have spotted 46 times.
Referring Clues:
- Victim of Hercules
 - Monster slain by Hercules
 - Nine-headed serpent of myth
 - Nine-headed serpent
 - Many-headed serpent
 - Monster in the second labor of Hercules
 - Victim of Hercules' second labor
 - Subject of a Herculean labor
 - Many-headed monster of myth
 - Monster with a head for multiplication and then some
 - Multiheaded serpent slain by Hercules
 - Many-headed monster
 - Sea Serpent constellation
 - Mythical serpent
 - Serpent with nine heads
 - Multiheaded beast slain by Hercules
 - Many-headed mythical monster
 - Beast that grew two heads every time it lost one
 - Many-headed challenge for Hercules
 - Longest constellation
 - Mythical multiheaded beast
 - Multiheaded monster
 - Resilient many-headed monster
 - Herculean opponent
 - Hercules' many-headed foe
 - Serpent slain by Hercules
 - See 21-Across
 - Freshwater polyp
 - Many-headed monster slain by Hercules
 - Creature Hercules fought
 - Monster raised by Hera
 - Beast battled by Hercules
 - Hercules slew it
 - Hercules' serpent adversary
 - S.H.I.E.L.D.'s enemy, in Marvel comics
 - One with many mouths to feed?
 - Southern constellation
 - Multiheaded monster of myth
 - Monster with many heads
 - Sea serpent in the night sky
 - Enemy organization in Marvel Comics
 - Multiheaded serpentine lake monster
 - Mythological nine-headed lake monster
 - Monster slain in one of Hercules' 12 labors
 - Sea serpent of myth
 - Mythological beast able to regenerate its heads
 
Last Seen In:
- New York Times - August 28, 2025
 - New York Times - July 11, 2025
 - New York Times - May 23, 2025
 - New York Times - May 13, 2025
 - USA Today - May 02, 2025
 - LA Times - November 28, 2024
 - USA Today - July 24, 2024
 - New York Times - September 09, 2022
 - New York Times - August 20, 2022
 - LA Times - December 13, 2021
 - LA Times - July 08, 2021
 - New York Times - January 09, 2021
 - Universal - December 14, 2020
 - New York Times - February 25, 2020
 - Universal - July 07, 2019
 - New York Times - December 26, 2018
 - New York Times - August 20, 2018
 - King Syndicate - Thomas Joseph - July 02, 2018
 - King Syndicate - Eugene Sheffer - June 25, 2018
 - New York Times - May 13, 2018
 
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