Answer: HEADACHE
HEADACHE is a crossword puzzle answer that we have spotted 27 times.
Referring Clues:
- Major annoyance
 - Problem
 - Annoying situation
 - Annoyance
 - Cephalalgia
 - Pain in the brain
 - Nuisance
 - Aspirin target
 - One reason for taking aspirin
 - Ibuprofen target
 - Major inconvenience
 - Big pain
 - Big bother
 - Migraine, for one
 - Vexatious problem
 - Bother
 - Migraine
 - Big problem
 - Vexing situation
 - Bothersome type
 - Worrying problem
 - Hangover symptom
 - Migraine, e.g.
 - Inconvenience
 - Pain in the butt, ironically
 - Source of worry
 - Something treated by Tylenol
 
Last Seen In:
- USA Today - September 30, 2024
 - Universal - May 08, 2021
 - LA Times - May 27, 2018
 - Universal - April 14, 2017
 - LA Times - March 05, 2017
 - Wall Street Journal - May 29, 2015
 - King Syndicate - Eugene Sheffer - May 06, 2014
 - Chicago Reader - October 18, 2013
 - Universal - October 16, 2013
 - Universal - August 27, 2013
 - LA Times - November 01, 2012
 - King Syndicate - Eugene Sheffer - October 15, 2012
 - Washington Post - August 01, 2012
 - King Syndicate - Eugene Sheffer - June 01, 2012
 - Washington Post - April 03, 2012
 - New York Times - January 22, 2012
 - King Syndicate - Eugene Sheffer - September 26, 2011
 - LA Times - September 05, 2010
 - Netword - August 29, 2010
 - New York Times - June 02, 2010
 
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